Fertil Steril . 2018 Jan; 109:20-26
\nLiina Nagirnaja, Ph.D.,a Kenneth I. Aston, Ph.D.,b and Donald F. Conrad, Ph.D.a
\na Department of Genetics, Washington University School of Medicine, St. Louis, Missouri; and b Department of Surgery,
\nUniversity of Utah School of Medicine, Salt Lake City, Utah<\/p>\n
Estudios epidemiol\u00f3gicos recientes han identificado una asociaci\u00f3n entre la infertilidad masculina y el aumento del riesgo de c\u00e1ncer, sin embargo, no se ha investigado la etiolog\u00eda subyacente para el riesgo compartido. Es probable que gran parte de la asociaci\u00f3n entre los dos estados de enfermedad puede atribuirse a lesiones gen\u00e9ticas subyacentes. En este art\u00edculo revisamos las asociaciones publicadas entre c\u00e1ncer y defectos espermatog\u00e9nicos, y a trav\u00e9s de b\u00fasquedas en bases de datos, identificamos genes candidatos y clases de genes que podr\u00edan explicar algunos de los puntos observados que comparten riesgo gen\u00e9tico Discutimos la importancia de caracterizar completamente la base gen\u00e9tica de la relaci\u00f3n entre el c\u00e1ncer e infertilidad masculina y proponer futuros estudios<\/p>\n
Comentario editorial: Ya en nuestro newsletter publicamos una revisi\u00f3n sobre la relaci\u00f3n de infertilidad y c\u00e1ncer (Fertil Steril. 2016 Feb;105(2):322-328 La subfertilidad aumenta el riesgo de c\u00e1ncer testicular: Evidencia basada en muestras de semen de una determinada poblaci\u00f3n). Se hace cada vez m\u00e1s necesario tener conocimientos de gen\u00e9tica para realizar un buen asesoramiento a los pacientes que acuden para estudio de infertilidad, ya que no s\u00f3lo debemos circunscribirnos al \u00e1mbito de la fertilidad si no a la preservaci\u00f3n de la salud del var\u00f3n en general.<\/p>\n
\nCarlos Balmori Boticario
\nUr\u00f3logo.
\nResponsable Secci\u00f3n Urolog\u00eda y Medicina Sexual y Reproductiva
\nCentros: Hospital N\u00aa Sra. del Rosario. IVI Madrid
\ncbalmori@unidadmedicinasexual.com
\nwww.unidadmedicinasexual.com<\/p>\n","protected":false},"excerpt":{"rendered":"
Fertil Steril . 2018 Jan; 109:20-26 Liina Nagirnaja, Ph.D.,a Kenneth I. Aston, Ph.D.,b and Donald F. Conrad, Ph.D.a a Department of Genetics, Washington University School of Medicine, St. Louis, Missouri; and b Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3,5,16],"tags":[],"class_list":{"0":"post-862","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-alertasurologia","7":"category-articulos-de-interes","8":"category-oncologia","9":"h-entry","10":"hentry","11":"h-as-article"},"_links":{"self":[{"href":"https:\/\/gua.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gua.aeu.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gua.aeu.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gua.aeu.es\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/gua.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=862"}],"version-history":[{"count":1,"href":"https:\/\/gua.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/862\/revisions"}],"predecessor-version":[{"id":863,"href":"https:\/\/gua.aeu.es\/index.php?rest_route=\/wp\/v2\/posts\/862\/revisions\/863"}],"wp:attachment":[{"href":"https:\/\/gua.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gua.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gua.aeu.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}